From an art/message standpoint, fantastic. From a game standpoint terrible.
To start there is no drive to actually play the game, coupled with the fact that the different disabilities have different levels of difficulty, while the disabilities are randomly generated makes the game "potentially very unfair", as you call it. This isn't good in terms of game design at all. I'd think of putting an interface in that lets you choose your disability. Then fact that you have varied jump force, with the amount of timed jumps isn't great either.
You didn't really fit the "You only get one" theme either, hiding the fact that you could just refresh the page to alter your game isn't only allowing one thing.. and you certainly didn't mean one life, because you mean for us to die.
I liked the message you portray, however the medium in which you have brought about that message is frustrating. People do not care about artist's message for the most part anyway (I don't have to tell you this seeing all the zero stared ratings). It's not that your game is "bad", it is the fact that it is not a part of a movement. Had this been on a web page or blog supporting people with disabilities (And the signs removed) it would have that movement behind the message you give.
Thanks for the experience.
~Jacob